Bioanalytical detection of NO, NO2, nitrate/nitrite/nitrosothiols, NO-heme, and other NO-metals in biological fluids such as blood, urine, cerebrospinal fluid, and bronchial-alveolar lavage, as well as cell culture media and tissue homogenates
Cell viability and cytotoxicity studies including dose and time-response, and determination of ID50 assessing gaseous NO/NO-donors in mammalian and prokaryotic cells
Custom synthesis and purification of NO-donor compounds from milligram (GLP) to kilogram (cGMP) scale
Characterization of NO-donors and kinetic NO-release profiles using multiple analytic platforms such as HPLC, UV/Vis, FTIR, and head-space chemiluminescence analysis
Design of custom projects tailored for NO delivery in a variety of R&D healthcare applications
Design and execution of pharmacokinetic and pharmacodynamic studies of NO donors undertaken with full IACUC approvals
Validation and analysis to support research & development, clinical and commercial needs
Gold standard analytical instrumentation and testing methods.