• Bioanalytical detection of NO, NO2, nitrate/nitrite/nitrosothiols, NO-heme, and other NO-metals in biological fluids such as blood, urine, cerebrospinal fluid, and bronchial-alveolar lavage, as well as cell culture media and tissue homogenates
  • Cell viability and cytotoxicity studies including dose and time-response, and determination of ID50 assessing gaseous NO/NO-donors in mammalian and prokaryotic cells
  • Custom synthesis and purification of NO-donor compounds from milligram (GLP) to kilogram (cGMP) scale
  • Characterization of NO-donors and kinetic NO-release profiles using multiple analytic platforms such as HPLC, UV/Vis, FTIR, and head-space chemiluminescence analysis
  • Design of custom projects tailored for NO delivery in a variety of R&D healthcare applications
  • Design and execution of pharmacokinetic and pharmacodynamic studies of NO donors undertaken with full IACUC approvals
  • Validation and analysis to support research & development, clinical and commercial needs
  • Gold standard analytical instrumentation and testing methods




 

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CONTRACT RESEARCH ORGANIZATION DEDICATED TO THE  Research and development of nitric oxide

 

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